What happens to your brain on LSD, mushrooms, or ayahuasca? Psychedelics down-regulate the brain’s default mode network, the “ego center”. Without the ego, your brain is “off the leash” able to interact in ways that produce hallucinations and synesthesia. Therapeutically, this ego death can quiet negative self talk and break bad thinking habits.
— Read on bigthink.com/videos/psychedelic-brain